Study Finds No Link Between Paracetamol Use in Pregnancy and Autism or ADHD

A recent study published in The Lancet confirms that maternal use of paracetamol during pregnancy does not elevate the risk of autism, ADHD, or intellectual disabilities in children. This research challenges earlier assertions made by former US President Donald Trump, who advised against the use of acetaminophen. The findings, derived from a comprehensive review of 43 studies, emphasize the medication's safety profile and highlight the potential risks of untreated pain and fever during pregnancy. Regulatory agencies worldwide support these conclusions, reinforcing paracetamol's status as a safe option for expectant mothers.

By Narendra Chaudhary Jan 17, 2026, 16:36 IST

New Research on Paracetamol Safety During Pregnancy

New Delhi, Jan 17: A recent study has concluded that the use of paracetamol by mothers during pregnancy does not increase the likelihood of autism, attention-deficit hyperactivity disorder (ADHD), or intellectual disabilities in their children. This finding contradicts previous claims made by former US President Donald Trump regarding the common pain relief medication.

During a White House event in September, Trump advised expectant mothers to endure pain instead of using acetaminophen, the active ingredient in Tylenol.

Paracetamol, known as acetaminophen, is the most widely used pain reliever and fever reducer during pregnancy. It is globally recommended as a primary option for managing pain and fever due to its favorable safety profile compared to non-steroidal anti-inflammatory drugs and opioids. It is also listed among the WHO's Essential Medicines.

The systematic review and meta-analysis, which encompassed 43 studies and was published in The Lancet Obstetrics, Gynaecology, & Women’s Health, reinforces existing guidelines regarding the safety of paracetamol during pregnancy.

According to Prof Asma Khalil from St George's University Hospitals in the UK, the study found no evidence linking maternal paracetamol use during pregnancy to an increased risk of autism spectrum disorder, ADHD, or intellectual disabilities in children. The results remained consistent across various analyses, including those with longer follow-up periods and sibling comparisons.

The research team, which included experts from the UK, Italy, and Sweden, indicated that earlier associations found in observational studies likely stem from confounding factors such as maternal illness, fever, genetic predispositions, or environmental influences, rather than a direct effect of paracetamol.

They cautioned that avoiding paracetamol could expose mothers and their unborn children to risks associated with untreated pain and fever, including miscarriage, preterm birth, or congenital anomalies.

Other international regulatory bodies, including the European Medicines Agency, the UK Medicines and Healthcare products Regulatory Agency, and Health Canada, also endorse the safety of paracetamol.