DNA Evidence May Still Be Present in Nancy Guthrie's Disappearance Case

The search for Nancy Guthrie, missing for over two months, continues as investigators explore potential DNA evidence at her home. Genetic genealogist CeCe Moore suggests that usable DNA may still be recoverable. The case has drawn significant attention, with multiple agencies involved and rewards offered for information. Authorities are urging the public to assist in the investigation while navigating complex DNA challenges. As the search intensifies, the community remains hopeful for Guthrie's safe return.

By Narendra Chaudhary Apr 15, 2026, 00:57 IST

Investigation into Nancy Guthrie's Disappearance

A genetic genealogist has suggested that there might still be DNA evidence at the residence of Nancy Guthrie, who has been missing for over two months. The 84-year-old, mother of Savannah Guthrie, was last seen at her Tucson, Arizona home on January 31. CeCe Moore, a genetic genealogist, mentioned in an interview that it is plausible to recover usable DNA from the location. "DNA is quite resilient, so it’s certainly feasible that some could still be present," she stated. She highlighted saliva as a potential source of evidence, referencing surveillance footage that captured an unidentified man near Guthrie's home on the day she vanished. "I believe saliva is the most likely source, especially considering the flashlight he seemed to have in his mouth," Moore added.

The investigation has mobilized multiple agencies, including local law enforcement and the FBI. Authorities have released images and video of a man suspected of tampering with a camera at the front of Guthrie's home. Investigators revealed they had obtained new images showing an armed individual interfering with the camera on the morning of her disappearance. Pima County Sheriff Chris Nanos indicated that there are signs suggesting Guthrie did not leave voluntarily. He also mentioned her need for daily medication, which could be life-threatening if missed.

Ransom notes have reportedly been sent to various media outlets, although their authenticity has not been verified by authorities. Investigators have examined several pieces of evidence, including a glove found two miles from Guthrie's home, which yielded no matches in the national DNA database, CODIS. The sheriff's department confirmed that there have been no CODIS matches thus far in this case. However, Sheriff Nanos stated that blood found on the porch belonged to Guthrie and that they are working with DNA believed to be usable. "I can’t disclose everything, but we have DNA that we think is still workable," he mentioned in an interview.

Officials have noted that the DNA could be complex, possibly containing genetic material from multiple individuals. Former FBI agent Jennifer Coffindaffer remarked that such complexity can complicate the investigation. "In my experience, it has been challenging to separate complex DNA profiles," she stated. Moore expressed confidence in the investigators' efforts, suggesting that they may not have swabbed the right areas to find the individual’s DNA, which is a common challenge in such cases. "In a house like that, where do you even begin?" she questioned.

Authorities are actively seeking public assistance. The FBI has announced a reward of up to $100,000 for information that leads to Guthrie's recovery or the arrest and conviction of those responsible. The FBI Phoenix office urged the public to provide only serious, fact-based information, avoiding well-wishes or speculative theories. Additionally, the organization 88-CRIME is offering a reward of $102,500, while Guthrie's family has set up a reward of up to $1 million for her safe return.