Joe Rogan Discusses Controversial Plasma Replacement Procedure

Joe Rogan has recently attracted attention by discussing a plasma replacement procedure he underwent, comparing it to changing oil in a car. He shared his experience on Instagram, showcasing bags of plasma and highlighting potential benefits like improved sleep and recovery. While some users expressed skepticism about the procedure's cost and effectiveness, others noted its established medical uses. This discussion reflects a growing interest in unconventional health practices among public figures. Experts caution that while such treatments may have clinical benefits, their use for general wellness remains a topic of ongoing research. Read on to discover more about Rogan's experience and the reactions it has generated.

By Narendra Chaudhary Mar 31, 2026, 05:36 IST

Joe Rogan's Plasma Procedure Explained

Joe Rogan has sparked significant online discussion after revealing details about a medical procedure where plasma is extracted from his blood and replaced. He likened this process to "changing the oil" in a vehicle. In an Instagram post, Rogan shared a photo of himself with three bags filled with an orange-yellow liquid, which he identified as plasma. He explained that the procedure involves removing plasma that contains "inflammatory proteins, toxins, and byproducts" and substituting it to enhance the body's functionality. He stated, "It's essentially like changing the oil in your body." Rogan noted that while the procedure may seem unusual, those he knows who have undergone it reported improvements in sleep quality and recovery times.

The method he described resembles plasmapheresis, a medical treatment that removes plasma from the bloodstream and replaces it with other fluids. This treatment is typically reserved for specific autoimmune or neurological disorders rather than general wellness applications.

Rogan characterized the experience as "crazy" and expressed eagerness to observe the outcomes and advancements in this area. He also mentioned new methods involving biologics that may be used in conjunction with plasma replacement. His post quickly garnered a variety of responses on social media. Some users voiced skepticism regarding the procedure's efficacy and cost, while others pointed out its recognized medical applications. One commenter labeled it as an "expensive" health trend, while another preferred to trust the body's natural blood filtration systems. Additionally, some shared personal anecdotes about similar treatments used for serious health issues. This conversation arises amid increasing interest in unconventional health practices among celebrities. In 2025, Bryan Johnson, a US entrepreneur known for exploring longevity treatments, also underwent a plasma removal and replacement procedure. Experts generally advise caution, noting that while such treatments may be beneficial in specific clinical scenarios, their broader application for wellness or performance enhancement is still under investigation.